Nabanita Saha
Tomas Bata University, Czech Republic
Title: Biomineralized (CaCO3) bacterial cellulose: A novel functional biomaterial
Biography
Biography: Nabanita Saha
Abstract
Bacterial cellulose (BC) based functional biomaterials represent an important challenge in biomaterial research for potential use in certain biomedical applications (e.g. scaffolds for bone tissue engineering). Credit goes to inherent properties of BC, such as porosity, density, water holding capacity, high strength (similar to the mechanical properties of cartilage), physical stability and relatively low degradation rate of cellulose inside the human body etc. Bone is a composite material with an organic phase (collagen and non-collagenous proteins) and an inorganic mineral phase (calcium hydroxyapatite). Moreover, it is proven that BC nanofibers can mimic collagen nanofibers for Ca-P mineral deposition via biomineralization. It is assumed that in near future, biomineralized bacterial cellulose (filled with calcium carbonate (CaCO3)) can be a substitute biomaterial for bone tissue engineering. Some work done on BC-hydroxyapatite (Hap) nanocomposites as similar kind of calcium deficient (Hap) found in natural bone but not much work done on BC-CaCO3.This paper will report about promotion of CaCO3 deposition on BC membranes using calcium chloride and sodium carbonate as starting reactants. The diffusion–driven mineralization technique has been implemented for the fabrication of CaCO3 within BC mat. The biomimetic mineralization study was performed for 0 to 60 min at stationary conditions. Several diverse shapes and sizes dispersed white crystal cubic structures are observed on BC mat. In conclusion, it can be mentioned that incubation period has great influence on biomimetic nucleation and formation of CaCO3. The precise information about BC biosynthesis and biomineralization process will be discussed during presentation.